Cancer Weekly
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Cancer Vaccines
Study data from Columbia University provide new insights into cancer vaccines
April 7th, 2009
According to recent research from the United States, "Interleukin- 2 (IL-2) induces durable objective responses in a small cohort of patients with metastatic renal cell carcinoma (RCC) but the antigen(s) responsible for tumor rejection are not known. 5T4 is a non-secreted membrane glycoprotein expressed on clear cell and papillary RCCs. A modified vaccinia virus Ankara (MVA) encoding 5T4 was tested in combination with high-dose IL-2 to determine the safety, objective response rate and effect on humoral and cell-mediated immunity." "25 patients with metastatic RCC who qualified for IL-2 were eligible and received three immunizations every three weeks followed by IL-2...
Source: Cancer Weekly (2009-04-07)
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