Cholangio Cancer

Recent findings from Kanazawa University, Medical Department highlight research in cholangio cancer

Published in Cancer Weekly, April 7th, 2009

According to recent research from Kanazawa, Japan, "Matrix metalloproteinase-9 (MMP-9) is an important enzyme in tumor invasion and metastasis in malignant tumors, including cholangiocarcinoma (CC). Tumor necrosis factor-alpha (TNF-alpha), a proinflammatory cytokine, was recently reported to induce the up-regulation of MMP-9 in cultured CC cells."

"We examined whether cyclooxygenase-2 (COX-2) and prostaglandin-E2 (PGF2), another endogenous tumor promoter, are involved in the up-regulation of MMP-9 in CC using CC tissue specimens and a CC cell line, HuCCT-1. MMP-9 and COX-2 were immunohistochemically expressed in 58% and 89% of 110 CC cases, respectively; the expression...

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Source: Cancer Weekly (2009-04-07)

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