Gene Therapy

Study data from University of Milan update knowledge of gene therapy

Published in Cancer Weekly, April 7th, 2009

"Cell-cycle defects are responsible for cancer onset and growth. We studied the expression profile of 60 genes involved in cell cycle in a series of malignant mesotheliomas (MMs), normal pleural tissues, and MM cell cultures using a quantitative polymerase chain reaction-based, low-density array," scientists in Milan, Italy report.

"Nine genes were significantly deregulated in MMs compared with normal controls. Seven genes were overexpressed. in MMs, including the following: CDKN2C, cdc6, cyclin H, cyclin B1, CDC2, FoxM1, and Chk1, whereas Ube1L and cyclin D2 were underexpressed. Chk1 is a principal mediator of cell-cycle checkpoints in response to genotoxic stress. We...

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Source: Cancer Weekly (2009-04-07)

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