Cancer Weekly
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Angiogenesis
Findings in angiogenesis reported from A. Albini and co-researchers
April 7th, 2009
"Angiostatin, an endogenous angiogenesis inhibitor, is a fragment of plasminogen. Its anti-angiogenic activity was discovered with functional assays in vivo, however, its direct action on endothelial cells is moderate and identification of definitive mechanisms of action has been elusive to date," scientists writing in the Journal of Translational Medicine report. "We had previously demonstrated that innate immune cells are key targets of angiostatin, however the pathway involved in this immune-related angiogenesis inhibition was not known. Here we present evidence that IL-12, a principal THI cytokine with potent anti-angiogenic activity, is the mediator of...
Source: Cancer Weekly (2009-04-07)
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