Cancer Gene Therapy

Studies from Polytechnic University have provided new information about cancer gene therapy

Published in Cancer Weekly, April 7th, 2009

"CD147 plays a critical role in the invasive and metastatic activity of hepatocellular carcinoma (HCC) cells by stimulating the surrounding fibroblasts to express matrix metalloproteinases (MMPs). Tumor cells adhesion to extracellular matrix (ECM) proteins is the first step to the tumor metastasis," scientists in Xian, People's Republic of China report.

"MMPs degrade the ECM to promote tumor metastasis. The aim of this study is to investigate the effects of small interfering RNA ( siRNA) against CD147 (si-CD147) on hepatocellular carcinoma cells' (SMMC-7721) architecture and functions. Flow cytometry and western blot assays were employed to detect the transfection...

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Source: Cancer Weekly (2009-04-07)

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