Cancer Weekly
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Cancer Weekly
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Immunization
Data on immunization detailed by researchers at Karolinska Institut, Department of Oncology
April 14th, 2009
New research, 'HER-2/neu mediated down-regulation of MHC class I antigen processing prevents CTL-mediated tumor recognition upon DNA vaccination in HLA-A2 transgenic mice,' is the subject of a report. According to recent research from Stockholm, Sweden, "To study DNA vaccination directed against human HER-2 in the HHD mouse Tg strain, we created a novel HER-2-expressing syngeneic tumor transplantation model. We found that a DNA vaccine encoding the full length HER-2 DNA protected HHD mice from HER-2(+) tumor challenge by a CTL independent mechanism." "A more efficient approach to induce HLA-A2 restricted CTLs, through immunization with a multi-epitope DNA vaccine...
Source: Cancer Weekly (2009-04-14)
|
