Immunization
Data on immunization detailed by researchers at Karolinska Institut, Department of Oncology
Published in Cancer Weekly, April 14th, 2009
New research, 'HER-2/neu mediated down-regulation of MHC class I antigen processing prevents CTL-mediated tumor recognition upon DNA vaccination in HLA-A2 transgenic mice,' is the subject of a report. According to recent research from Stockholm, Sweden, "To study DNA vaccination directed against human HER-2 in the HHD mouse Tg strain, we created a novel HER-2-expressing syngeneic tumor transplantation model. We found that a DNA vaccine encoding the full length HER-2 DNA protected HHD mice from HER-2(+) tumor challenge by a CTL independent mechanism."
"A more efficient approach to induce HLA-A2 restricted CTLs, through immunization with a multi-epitope DNA vaccine...
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Source: Cancer Weekly (2009-04-14)
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