Cancer Weekly
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Acute Lymphoblastic Leukemia
New acute lymphoblastic leukemia research has been reported by scientists at University Children's Hospital
April 14th, 2009
"Karyotype analysis of acute lymphoblastic leukemia (ALL) at diagnosis has provided valuable prognostic markers for treatment stratification. However, reports of cytogenetic studies of relapsed ALL samples are limited," scientists in Zurich, Switzerland report. "We compared the karyotypes from 436 nonselected B-cell precursor ALL patients at initial diagnosis and of 76 patients at first relapse. We noticed a relative increase of karyotypes that did not fall into the classic ALL cytogenetic subgroups (high hyperdiploidy, t(12;21), t(9;22), 11q23, t(1; 19), < 45 chromosomes) in a group of 29 patients at relapse (38%) compared to 130 patients at presentation (30%)....
Source: Cancer Weekly (2009-04-14)
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