Life Sciences

Scientists at University of Versailles describe research in life sciences

Published in Cancer Weekly, April 14th, 2009

According to recent research from Versailles, France, "We describe the synthesis of an 11 beta isomer 3 of the steroidal antiestrogen fulvestrant 2. Partial fluorination of the 11 beta side chain in 3 leads to 4, which still shows strong antiproliferative activity on MCF-7 cells."

"However, unlike 2 and 3, compound 4 fails to down-regulate estrogen receptor alpha (ER alpha)," wrote V. Agouridas and colleagues, University of Versailles.

The researchers concluded: "This result suggests that ER alpha down-regulation is not a sine qua non condition for the antitumor activity of steroidal antiestrogens."

Agouridas and colleagues...

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Source: Cancer Weekly (2009-04-14)

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