Osteosarcoma

Research on osteosarcoma discussed by A. Kumarasuriyar and co-researchers

Published in Cancer Weekly, April 14th, 2009

"Osteogenic differentiation is coordinated by the. exposure of cells to temporal changes in a combination of growth factors and elements within the extracellular matrix (ECM). Many of the key proteins that drive these changes share the property of being dependent on ECM glycosaminoglycans (GAGs) for their activity," scientists writing in the Journal of Cellular Physiology report.

"Here, we examined whether GAGs isolated from proliferating, differentiating and mineralizing MG-63 osteosarcoma cells differed in their physical properties, and thus in their capacities to coordinate the osteogenic cascade both in human MG-63 osteosarcoma cells and primary human...

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Source: Cancer Weekly (2009-04-14)

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