Published in Cancer Weekly, April 14th, 2009
"The expression of mTOR in patient specimens and in a panel of SCLC cell lines was analyzed. The effects on SCLC cell survival and downstream signaling were determined following mTOR inhibition by the rapamycin derivative RAD001 (Everolimus) or down-regulation by small interfering RNA. We found elevated expression of mTOR in patient specimens and SCLC cell lines,...
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