Cancer Weekly
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Bioengineering
Data on bioengineering published by M. Quanz and colleagues
April 14th, 2009
"Enhanced DNA repair activity is often associated with tumor resistance to radiotherapy. We hypothesized that inhibiting DNA damage repair would sensitize tumors to radiation-induced DNA damage," investigators in Orsay, France report. "A novel strategy for inhibiting DNA repair was tested. We designed small DNA molecules that mimic DNA double-strand breaks (called Dbait) and act by disorganizing damage signaling and DNA repair. We analyzed the effects of Dbait in cultured cells and on xenografted tumors growth and performed preliminary studies of their mechanism(s) of action. The selected Dbait molecules activate H2AX phosphorylation in cell culture and in xenografted...
Source: Cancer Weekly (2009-04-14)
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