Cancer Weekly
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Life Sciences
Studies from University of Guelph in the area of life sciences published
April 21st, 2009
"The solution conformational behavior of the Tumor-Associated Carbohydrate Antigen Le(a)Le(x) central fragment: methyl alpha-L-fucopyranosyl-(1 -> 4)-2-acetamido-2-deoxy-beta-D-glucopyranosyl-(1 -> 3)-beta-D-galactopyranoside was studied using three computational methods: a rigid systematic search as implemented in Sybyl, a stochastic search as implemented in MOE2004, and dynamics simulations using the SANDER module of AMBER9," researchers in Guelph, Canada report. "Our results illustrate the complementarity of these methods to identify energetically relevant conformations and flexible linkages. In particular, the beta-GlcNAc-(1 -> 3)-Gal linkage was shown to...
Source: Cancer Weekly (2009-04-21)
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