Cancer Weekly
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Cancer Gene Therapy
Research from University of Georgia, Research Center has provided new information about cancer gene therapy
April 21st, 2009
Scientists discuss in 'Knockdown of GnT-Va expression inhibits ligand-induced downregulation of the epidermal growth factor receptor and intracellular signaling by inhibiting receptor endocytosis' new findings in cancer gene therapy. "Changes in the expression of N-glycan branching glycosyltransferases can alter cell surface receptor functions, involving their levels of cell surface retention, rates of internalization into the endosomal compartment, and subsequent intracellular signaling. To study in detail the regulation of signaling of the EGF receptor (EGFR) by GlcNAcbeta(1,6)Man branching, we utilized specific siRNA to selectively knockdown GnT-Va expression in the highly invasive...
Source: Cancer Weekly (2009-04-21)
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