Cancer Weekly
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Cancer Vaccines
Researchers from University of London, Imperial College provide details of new studies and findings in the area of cancer vaccines
April 21st, 2009
According to a study from London, the United Kingdom, "Abnormal glycosylation is one of the hallmarks of the cancer cell and is associated with tumor invasion and metastasis. The development of tumor-associated carbohydrate antigen (TACA) vaccines has been problematic due to poor immunogenicity." "However, when appropriate targets can be identified, passive immunization with monoclonal antibodies (mAbs) directed against TACAs has been shown to have antitumor activity. Fas ligand (FasL) is a transmembrane protein that induces apoptosis in cells expressing its receptor, Fas. When grafted into mice, FasL-expressing tumor cells break immunologic tolerance to self-antigens...
Source: Cancer Weekly (2009-04-21)
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