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Leukemia Gene Therapy
New research on leukemia gene therapy from University Hospital summarized
April 21st, 2009
New investigation results, 'Reduced proliferation of CD34(+) cells from patients with acute myeloid leukemia after gene transfer of INPP5D,' are detailed in a study published in Gene Therapy. According to recent research from Hamburg, Germany, "Acute myeloid leukemia (AML) is a malignant disease characterized by deregulated proliferation of immature myeloid cells. Constitutive activation of the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway is frequently detected in approximately 50-70% of AML patients." "The gene INPP5D encodes the SH2-containing inositol 5-phosphatase 1 (SHIP1), which is a negative regulator of PI3K/AKT signaling. After...
Source: Cancer Weekly (2009-04-21)
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