Liposarcoma

Research from University of Milan yields new findings on liposarcoma

Published in Cancer Weekly, April 21st, 2009

According to recent research from Milan, Italy, "Differentiation is a complex set of events that can be blocked by rearrangements of regulatory genes producing fusion proteins with altered properties. In the case of myxoid liposarcoma (MLS) tumors, the causative abnormality is a fusion between the CHOP transcription factor and the FUS or EWS genes."

"CHOP belongs to and is a negative regulator of the large CAAT/enhancer binding protein family whose alpha, beta, and delta members are master genes of adipogenesis. Recent clinical data indicate a peculiar sensitivity of these tumors to the natural marine compound trabectedin. One hypothesis is that the activity of...

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Source: Cancer Weekly (2009-04-21)

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