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Leukemia Gene Therapy
New research on leukemia gene therapy from University of Ulm, Department of Internal Medicine III summarized
April 21st, 2009
New research, 'Chronic lymphocytic leukemia and 13q14: miRs and more,' is the subject of a report. According to a study from Ulm, Germany, "Loss of a critical region in 13q14.3 [del(13q)] is the most common genomic aberration in chronic lymphocytic leukemia (CLL), occurring in more than 50% of patients (Stilgenbauer et al., Oncogene 1998;16:1891 -1897, Dohner et al., N Engl J Med 2000;343:1910 -1916). Despite extensive investigations, no point mutations have been found in the remaining allele that would inactivate one of the candidate tumor suppressor genes and explain the pathomechanism postulated for this region." "However, the genes in the region are significantly...
Source: Cancer Weekly (2009-04-21)
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