Cancer Weekly
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Acute Myeloid Leukemia
New data from Ernst-Moritz-Arndt University illuminate research in acute myeloid leukemia
April 21st, 2009
"Successful treatment of acute myeloid leukemia (AML) remains a therapeutic challenge, with a high percentage of patients suffering from persistent or relapsed disease. Resistance to drug therapy can develop from increased drug export and/or altered intracellular signaling," scientists in Greifswald, Germany report. "Both mechanisms are mediated by the efflux transporters ABCC4 (MRP4), ABCC5 (MRP5), and ABCC11 (MRP8), which are involved in cellular efflux of endogenous signaling molecules (e.g., cyclic adenosine 3',5'-monophosphate and cyclic guanosine 3',5'-monophosphate) and nucleoside analogues. The nucleoside analogue cytosine arabinoside (AraC) is administered to...
Source: Cancer Weekly (2009-04-21)
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