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Adenovirus
Research from Third Military Medical University broadens understanding of adenovirus
April 21st, 2009
"Oncolytic virus H101 is an adenovirus with an E1B-55KD gene deletion, which selectively replicates in tumor cells, rather than in normal cells, resulting in specific tumor cytolysis. Taking the selective killing of peritoneally planted tumor cells by the oncolytic virus H101 as the rationale for the ascites treatment, we report in this paper the intraperitoneal H101 in 9 patients with malignant ascites," investigators in Chongqing, People's Republic of China report. "The interval between the paracentesises increased from a mean of 12.4 +/- 3.4 to 39.9 +/- 11.6 days (p < 0.001). The 30-day response was classified into complete response (CR) (no fluid recurrence),...
Source: Cancer Weekly (2009-04-21)
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