Cancer Weekly
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Angiogenesis
Findings from M. Peled and co-authors broaden understanding of angiogenesis
April 21st, 2009
According to recent research published in the journal Clinical Cancer Research, "Angiogenesis is an essential process for solid tumor development. To interfere with angiogenesis, AdPPE3x-E1, an adenovirus that is transcriptionally targeted to replicate in angiogenic endothelial cells, was constructed, by replacing the E1 promoter with the modified preproendothelin-1 promoter, PPE-1-3x, previously shown to induce specific transcription in angiogenic endothelial cells." "The specificity of AdPPE3x-E1 to endothelial cells was shown by quantitative PCR and immunostaining, and its antiangiogenic effect was evaluated in Matrigel models. The in vivo efficacy of Ad...
Source: Cancer Weekly (2009-04-21)
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