Cancer Weekly
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Angiogenesis
New angiogenesis data have been reported by scientists at Northwestern University
April 21st, 2009
"Pigment epithelial-derived factor (PEDF) is a potent angiogenesis inhibitor with multiple other functions, some of which enhance tumor growth. Our previous studies mapped PEDF antiangiogenic and prosurvival activities to distinct epitopes," scientists writing in the journal Clinical Cancer Research report. "This study was aimed to determine the minimal fragment of PEDF, which maintains antiangiogenic and antitumor efficacy. We analyzed antigenicity, hydrophilicity, and charge distribution of the angioinhibitory epitope (the 34-mer) and designed three peptides covering its COOH terminus, P14, P18, and P23. We analyzed their ability to block endothelial cell...
Source: Cancer Weekly (2009-04-21)
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