Cancer Vaccines
Studies from University of Miami, Medical Department have provided new information about cancer vaccines
Published in Cancer Weekly, April 21st, 2009
According to recent research from the United States, "Established tumors suppress antitumor immune responses and induce tolerance by incompletely characterized mechanisms, and this phenomenon is an important barrier to tumor immunotherapy. Single vaccination with tumor cells expressing gp96-Ig stimulates robust expansion of tumor-specific CTLs in tumor-naive mice and this expansion is inhibited by established tumors."
"Interestingly, frequent vaccinations restore antitumor immune responses in the presence of established tumors. Syngeneic EG7 tumor-bearing mice have heterogeneous responses to frequent vaccination with EG7-gp96-Ig, with 32% complete responders and 68%...
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Source: Cancer Weekly (2009-04-21)
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