Cancer Weekly
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Angiogenesis
Studies from University of California describe new findings in angiogenesis
April 21st, 2009
According to recent research from the United States, "Multiple angiogenesis inhibitors have been therapeutically validated in preclinical cancer models, and several in clinical trials." "Here we report that angiogenesis inhibitors targeting the VEGF pathway demonstrate antitumor effects in mouse models of pancreatic neuroendocrine carcinoma and glioblastoma but concomitantly elicit tumor adaptation and progression to stages of greater malignancy, with heightened invasiveness and in some cases increased lymphatic and distant metastasis. Increased invasiveness is also seen by genetic ablation of the Vegf-A gene in both models, substantiating the results of the...
Source: Cancer Weekly (2009-04-21)
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