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Angiogenesis
Studies from Uppsala University further understanding of angiogenesis
April 21st, 2009
"Shb (Src homology 2 protein B) is an adapter protein downstream of the vascular endothelial growth factor receptor receptor-2 (VEGFR-2). Previous experiments have suggested a role for Shb in endothelial cell function," investigators in Uppsala, Sweden report. "Recently, the Shb gene was inactivated and Shb null mice were obtained on a mixed genetic background, but not on C57B16 mice. The present study was performed to address endothelial function in the Shb knockout mouse and its relevance for tumor angiogenesis. Tumor growth was retarded in Shb mutant mice, and this correlated with decreased angiogenesis both in tumors and in Matrigel plugs. Shb null mice display an...
Source: Cancer Weekly (2009-04-21)
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