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Gonadoblastoma Genetics

Research from University of California, Department of Medicine provide new insights into gonadoblastoma genetics

Published in Cancer Weekly, April 21st, 2009

A report, 'Gonadoblastoma locus and the TSPY gene on the human Y chromosome,' is newly published data in Birth Defects Research Part C, Embryo Today. According to recent research from the United States, "The gonadoblastoma (GBY) locus is the only oncogenic locus on the human Y chromosome. It is postulated to serve a normal function in the testis, but could exert oncogenic effects in dysgenetic gonads of individuals with intersex and/or dysfunctional testicular phenotypes."

"Recent studies establish the testis-specific protein Y-encoded (TSPY) gene to be the putative gene for GBY. TSPY serves normal functions in male stem germ cell proliferation and...

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