Cancer Weekly
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Apoptosis
Studies from M.J. Parsons and colleagues yield new information about apoptosis
April 21st, 2009
According to recent research from the United States, "Ductal carcinoma in situ (DCIS) is characterized by ductal epithelial cells that have filled the luminal space of the breast duct and survive despite loss of extracellular matrix contact. In normal epithelial cells, the loss of such contact triggers a form of apoptosis known as detachment-induced apoptosis or ''anoikis.'' TMS1/ASC is a bipartite adaptor molecule that participates in inflammatory and apoptotic signaling pathways." "Epigenetic silencing of TMS1 has been observed in a significant proportion of human breast and other cancers, but the mechanism by which TMS-1 silencing contributes to carcinogenesis is...
Source: Cancer Weekly (2009-04-21)
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