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Cancer Gene Therapy
Study findings from University of Rome, Institute of Molecular Biology and Pathology broaden understanding of cancer gene therapy
April 28th, 2009
Scientists discuss in 'RanBP1 downregulation sensitizes cancer cells to taxol in a caspase-3-dependent manner' new findings in cancer gene therapy. "Mitotic microtubule (MT)-targeting drugs are widely used to treat cancer. The GTPase Ran regulates multiple processes, including mitotic spindle assembly, spindle pole formation and MT dynamics; Ran activity is therefore essential to formation of a functional mitotic apparatus," investigators in Rome, Italy report. "The RanBP1 protein, which binds Ran and regulates its interaction with effectors, is overexpressed in many cancer types. Several observations indicate that RanBP1 contributes to regulate the function of the...
Source: Cancer Weekly (2009-04-28)
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