Cancer Weekly
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Acute Myeloid Leukemia
Study results from Malmo University broaden understanding of acute myeloid leukemia
April 28th, 2009
"Activating mutations of codon 816 of the Kit gene have been implicated in malignant cell growth of acute myeloid leukemia (AML), systemic mastocytosis and germ cell tumors. Substitution of aspartic acid with valine (D816V) renders the receptor independent of ligand for activation and signaling," scientists in Malmo, Sweden report. "Wild-type c-Kit is a tyrosine kinase receptor that requires its ligand, stem cell factor (SCF), for activation. Several isoforms of c-Kit exist as a result of alternative mRNA splicing, of which two are characterized by the presence or absence of four amino acids (GNNK- and GNNK+, respectively) in the extracellular domain. The two isoforms...
Source: Cancer Weekly (2009-04-28)
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