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Angiogenesis
Findings from National Institutes of Health in angiogenesis reported
April 28th, 2009
According to a study from the United States, "Vascular endothelial growth factor (VEGF) is a potent mitogen and permeability factor for endothelial cells that plays a central role in angiogenesis, vascular maintenance, inflammation, and cancer. VEGF also mediates the homeostatic adaptation to hypoxic conditions by promoting an increase in vascular density to compensate for decreased oxygenation." "This process is triggered by an oxygen-sensitive transcription factor, hypoxia-inducible factor-1 (HIF1 alpha), which becomes active in hypoxic tissues, leading to the synthesis and secretion of VEGF. The role of HIF1 alpha in other processes that involve angiogenesis such as...
Source: Cancer Weekly (2009-04-28)
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