Cancer Weekly
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Apoptosis
Research from I. Iurisci and co-authors reveals new findings on apoptosis
April 28th, 2009
According to recent research from Chieti, Italy, "Galectins have emerged as critical regulators of tumor progression and metastasis, by modulating different biological events including homotypic cell aggregation, apoptosis, migration, angiogenesis and immune escape. Therefore, galectin inhibitors might represent novel therapeutic agents for cancer." "A series of structural analogs of the disaccharide methyl P-lactosaminide were screened as potential galectin inhibitors by examining their capability to block binding of galectin-1 and/or galectin-3 to LGalS3BP in solid-phase assays. To demonstrate any functional role in vitro, oligosaccharides were characterized by their...
Source: Cancer Weekly (2009-04-28)
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