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B-Cell Lymphoma
New B-cell lymphoma data have been reported by P. Bolitho and co-authors
April 28th, 2009
According to recent research from Melbourne, Australia, "In the present study, we have examined the effect of perforin (pfp) deficiency in 4 models of mouse B-cell lymphomagenesis. We have examined pfp loss on the background of either Mlh1 tumor suppressor allele loss or oncogene expression [Ig heavy chain (E mu)-v-Abl, E mu-myc, and vav-bcl2]." "Pfp was shown to act as a suppressor of B-cell malignancies characteristically driven by v-Abl or bcl-2, whereas Mlh loss cooperated in accelerating spontaneous B-cell lymphomas characteristic of pfp loss. No protective role for pfp was observed in the more aggressive E mu-myc model of B-cell lymphoma," wrote P. Bolitho and...
Source: Cancer Weekly (2009-04-28)
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