Cancer Weekly
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Brain Cancer
Studies from Brain Tumor Center in the area of brain cancer published
April 28th, 2009
"Survivin has gained attention as a tumor-specific marker which is upregulated in a variety of neoplasms. Although the survivin protein is implicated in anti-apoptotic tumor pathways, little is known about the function of the survivin promoter," investigators in the United States report. "In this study, we constructed a conditionally replicative adenoviral vector (CRAB) that utilizes the survivin promoter and examined the mechanism of CRAB induced cell death in malignant glioma. Our results indicate that CRAB vectors which utilize the survivin promoter effectively replicate in glioma cells and exhibit a high oncolytic effect. The survivin-mediated CRAB appeared to...
Source: Cancer Weekly (2009-04-28)
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