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Cancer Weekly

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Life Sciences



Investigators at Johns Hopkins University, Medical Department release new data on life sciences



May 5th, 2009

According to a study from the United States, "Immune evasion is an important reason why the immune system cannot control tumor growth. To elucidate the mechanism for tumor immune evasion, we generated an immune-resistant human papillomavirus type 16 (HPV-16) E7-expressing tumor cell line by subjecting a susceptible tumor cell line to multiple rounds of in vivo immune selection with an E7-specific vaccine."

"Comparison of parental and immune-resistant tumors revealed that Akt is highly activated in the immune-resistant tumors. Retroviral transfer of a constitutively active form of Akt into the parental tumor significantly increased its resistance against E7-specific...


Source: Cancer Weekly (2009-05-05)

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