Cancer Gene Therapy
Researchers from University of Pittsburgh, Department of Immunology discuss findings in cancer gene therapy
Published in Cancer Weekly, May 5th, 2009
New investigation results, 'Lentiviral vectors encoding human MUC1-specific, MHC-unrestricted single-chain TCR and a fusion suicide gene: potential for universal and safe cancer immunotherapy,' are detailed in a study published in Cancer Immunology, Immunotherapy. "MUC1 tumor antigen is a target for immunotherapy of most human adenocarcinomas and some hematological malignancies. Expression of a MUC1-specific, MHC-unrestricted single-chain T cell receptor (scTCR) on cells of both innate and adaptive immune system through reconstitution of lethally irradiated mice by retroviral vector-transduced bone marrow cells, had been shown to effectively control the growth of MUC1(+) tumors...
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Source: Cancer Weekly (2009-05-05)
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