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Colon Cancer

Research from Chonnam National University, Medical Department yields new findings on colon cancer

Published in Cancer Weekly, May 5th, 2009

"KITENIN was previously reported to promote metastasis in mouse colon tumour models; however, the signalling mechanism of KITENIN at the cellular level was unknown. Here the functional role of KITENIN with respect to colorectal cancer (CRC) cell invasion and its expression in CRC tissues were investigated," scientists in South Korea report.

"The effect of KITENIN on cell motility was analysed in a migration and invasion assay upon its overexpression and knockdown. Immunoprecipitation was used to elucidate binding partners, and immunohistochemistry was used to study expression levels. KITENIN overexpression enhanced the migration of rat intestinal epithelial cells,...

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