DNA Research

Findings from B. Jakob et al in DNA research reported

Published in Cancer Weekly, May 5th, 2009

According to a study from Darmstadt, Germany, "We studied the spatiotemporal organization of DNA damage processing by live cell microscopy analysis in human cells. In unirradiated U2OS osteosarcoma and HeLa cancer cells, a fast confined and Brownian-like motion of DNA repair protein foci was observed, which was not altered by radiation."

"By analyzing the motional activity of GFP-53BP1 foci in live cells up to 12-h after irradiation, we detected an additional slower mobility of damaged chromatin sites showing a mean square displacement of approximate to 0.6 mu m(2)/h after exposure to densely- or sparsely-ionizing radiation, most likely driven by normal diffusion of...

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Source: Cancer Weekly (2009-05-05)

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