DNA Research

Findings from J. Galleani and co-researchers advance knowledge in DNA research

Published in Cancer Weekly, May 5th, 2009

According to recent research published in the journal Thyroid, "Papillary thyroid carcinoma (PTC) represents the most frequent thyroid neoplasia and is associated with radiation exposure. A consistent proportion of PTC is characterized by chromosome rearrangements producing RET and TRK oncogenes, but the mechanisms underlying the thyrocyte propensity to such alterations are poorly understood."

"Diminished capacity of thyrocytes to repair radiation-induced DNA double strand breaks (DSBs) might play a role in chromosome rearrangements; however, this question has not been fully addressed due to the lack of physiologically relevant experimental models. Several normal...

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Source: Cancer Weekly (2009-05-05)

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