Cancer Weekly
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Amyloidosis
New amyloidosis findings from University of Pavia described
May 5th, 2009
"In dialysis-related amyloidosis, beta 2-microglobulin accumulates as amyloid fibrils preferentially around bones and tendons provoking osteoarthritis. In addition to the pathologic role played by the amyloid fibrils, it can be speculated that a pathogenic role is also played by the high concentrations of soluble beta 2-microglobulin because it is toxic for certain cell lines like HL60 and mitogen for other cells such as the osteoclasts," investigators in Pavia, Italy report. "The discovery that beta 2-microglobulin can influence the biology of certain cells may lead to the assumption that it might affect neuronal cells that are quite sensitive to amyloidogenic proteins...
Source: Cancer Weekly (2009-05-05)
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