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Large-Cell Lymphoma

Reports from University of Texas add new data to research in large-cell lymphoma

Published in Cancer Weekly, May 5th, 2009

"Clusterin expression is common in systemic and cutaneous anaplastic large cell lymphoma (ALCL). Mycosis fungoides (MF) in large cell transformation can resemble ALCL," scientists in the United States report.

"In this study, we immunohistochemically assessed for clusterin in 97 skin biopsy specimens, including 70 MF eases and 27 other cutaneous neoplasms including ALCL, peripheral T-cell lymphoma unspecified (PTCL), and lymphomatoid papulosis (LyP). Clustel-in was positive in 36 (51%) of 70 cases of MF and correlated with clinical stage in 68 cases: 3 of 21 stage I, II of 20 stage II, and 23 of 27 stage III/IV. Clusterin expression also correlated with type of skin...

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