Cancer Weekly
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Cancer Gene Therapy
Research conducted at University of Marburg, Medical Department has updated our knowledge about cancer gene therapy
May 5th, 2009
"Evaluation of: Sonoke S, Ueda T, Fujiwara K et al.: Tumor regression in mice by delivery of Bcl-2 small interfering RNA with pegylated cationic liposomes. Cancer Res. 68, 8843-8851 (2008). The induction of RNAi, which represents a powerful, naturally occurring knockdown mechanism of (pathologically relevant) genes, can be achieved through the delivery of siRNAs," scientists in Marburg, Germany report. "Here, PEGylated siRNA/cationic liposome (slRNA/PEG-LIC) complexes are studied as a nonviral delivery platform for therapeutic siRNAs. siRNA/PEG-LIC complexes show favorable pharmacokinetic properties and biodistribution profiles over non-PEGylated complexes, with C-17 or...
Source: Cancer Weekly (2009-05-05)
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