Cancer Weekly
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Anti-Infectives
New anti-infectives findings from A. Alam and co-authors described
May 5th, 2009
According to a study from Solan, India, "Podophyllotoxin and its structural derivatives, a class of tubulin polymerization inhibitors, have been the objective of numerous studies to prepare better and safer anti-cancer drugs. A library of podophyllotoxin analogues has been designed consisting of 154 analogues." "Their molecular interactions and binding affinities with tubulin protein (1SA1) have been studied using the docking-molecular mechanics based on generalized Born/surface area (MM-GBSA) solvation model. Quantitative structure activity relationships were developed between the cytotoxic activity (pIC(50)) of these compounds and molecular descriptors like docking...
Source: Cancer Weekly (2009-05-05)
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