Cancer Weekly
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Barrett Esophagus
Study data from Y. Huang and co-authors update knowledge of barrett esophagus
May 5th, 2009
"The frequency of oesophageal adenocarcinoma is increasing in Western countries for unknown reasons, and correlates with a corresponding increase in the pre-malignant condition, Barrett's Oesophagus, which raises the risk of adenocarcinoma by some 40- to 125-fold. We have examined how disease progression correlates with changes in expression of the p14ARF (ARF) tumour suppressor, a key regulator of the p53 tumour suppressor pathway that is silenced in some 30% of cancers overall, but for which a role in oesophageal cancer is unclear," investigators in the United States report. "We have used quantitative PCR, RT-PCR, methylation-specific PCR and...
Source: Cancer Weekly (2009-05-05)
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