Breast Cancer

Research from R.E. Ellsworth et al broadens understanding of breast cancer

Published in Cancer Weekly, May 5th, 2009

"The most important predictor of prognosis in breast cancer is lymph node status, yet little is known about molecular changes associated with lymph node metastasis. Here, gene expression analysis was performed on primary breast (PBT) and corresponding metastatic lymph node (MLN) tumors to identify molecular signatures associated with nodal metastasis," investigators in the United States report.

"RNA was isolated after laser microdissection from frozen PBT and MLN from 20 patients with positive lymph nodes and hybridized to the microarray chips. Differential expression was determined using Mann-Whitney testing; Bonferroni corrected P values of 0.05 and 0.001 were...

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Source: Cancer Weekly (2009-05-05)

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