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Gene Therapy
Recent studies by D. Hoangle and co-authors add new data to gene therapy findings
May 5th, 2009
"We have recently developed a non-cytopathic RNA replicon-based viral vector system based on the flavivirus Kunjin. Here, we illustrate the utility of the Kunjin replicon system for gene therapy," researchers in Brisbane, Australia report. "Intra-tumoral injections of Kunjin replicon virus-like particles encoding granulocyte colony-stimulating factor were able to cure >50% of established subcutaneous CT26 colon carcinoma and B16-OVA melanomas. Regression of CT26 tumours correlated with the induction of anticancer CD8 T cells, and treatment of subcutaneous CT26 tumours also resulted in the regression of CT26 lung metastases," wrote D. Hoangle and colleagues. ...
Source: Cancer Weekly (2009-05-05)
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