Cancer Weekly
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Cancer Gene Therapy
Data on cancer gene therapy detailed by researchers at INSERM
May 12th, 2009
According to recent research from France, "The lack of safe and efficient systemic gene delivery vectors has largely reduced the potential of gene therapy in the clinic. Previously, we have reported that polypropylenimine dendrimer PPIG3/DNA nanoparticles are capable of tumor transfection upon systemic administration in tumor-bearing mice." "To be safely applicable in the clinic, it is crucial to investigate the colloidal stability of nanoparticles and to monitor the exact biodistribution of gene transfer in the whole body of the live subject. Our biophysical characterization shows that dendrimers, when complexed with DNA, are capable of forming spontaneously in...
Source: Cancer Weekly (2009-05-12)
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