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Cancer Gene Therapy
Findings from Qingdao University broaden understanding of cancer gene therapy
May 12th, 2009
According to a study from Qingdao, People's Republic of China, "CD59, belonging to membrane complement regulatory proteins (mCRPs), inhibits the cytolytic activity of complement and is over-expressed in solid cancers, including ovary cancer. The aim of the present study was to construct recombinant retrovirus encoding shRNA targeted human CD59 and infect A2780 cells in order to investigate the relationship between decreased CD59 expression and tumorigenesis of ovary cancer. siCD59 and siCD59-C were successfully constructed and identified by PCR, restriction endonuclease analyses and DNA sequencing, respectively." "The siCD59 was able to efficiently infect A2780 cells,...
Source: Cancer Weekly (2009-05-12)
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