Cancer Weekly
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Amelanotic Melanoma
Data from La Sapienza University provide new insights into amelanotic melanoma
May 12th, 2009
"Melanin synthesis, the elective trait of melanocytes, is regulated by tyrosinase activity. In tyrosinase-positive amelanotic melanomas this rate limiting enzyme is inactive because of acidic endo-melanosomal pH," scientists in Rome, Italy report. "The E5 oncogene of the Human Papillomavirus Type 16 is a small transmembrane protein with a weak transforming activity and a role during the early steps of viral infections. E5 has been shown to interact with 16 kDa subunit C of the transmembrane Vacuolar ATPase proton pump ultimately resulting in its functional suppressions. However, the cellular effects of such an interaction are still under debate. With this work we...
Source: Cancer Weekly (2009-05-12)
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