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Angiogenesis
Scientists at Harvard University, Medical Department report research in angiogenesis
May 12th, 2009
According to a study from the United States, "Angiogenin (ANG) undergoes nuclear translocation and stimulates rRNA transcription in both prostate cancer cells and endothelial cells. The purpose of this study is to assess the antitumor activity of neamine, a nontoxic degradation product of neomycin that blocks nuclear translocation of ANG." "The anti-prostate cancer activity of neamine was first evaluated in a xenograft animal model. It was then examined in the murine prostate-restricted AKT transgenic mice that develop prostate intraepithelial neoplasia (PIN) owing to AKT transgene overexpression. Neamine inhibits xenograft growth of PC-3 human prostate cancer cells in...
Source: Cancer Weekly (2009-05-12)
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