Cancer Weekly
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Breast Cancer
Findings in breast cancer reported from Ohio State University
May 12th, 2009
According to recent research from the United States, "An increasing amount of experimental evidence shows that microRNAs can have a causal role in breast cancer tumorigenesis as a novel class of oncogenes or tumor suppressor genes, depending on the targets they regulate. HER2 overexpression is a hallmark of a particularly aggressive subset of breast tumors, and its activation is strictly dependent on the trans-interaction with other members of HER family; in particular, the activation of the PI3K/Akt survival pathway, so critically important in tumorigenesis, is predominantly driven through phosphorylation of the kinase-inactive member HER3." "Here, we show that...
Source: Cancer Weekly (2009-05-12)
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