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Cancer Gene Therapy
New cancer gene therapy study results reported from Keimyung University, Institute for Medical Science
May 19th, 2009
Data detailed in 'Rottlerin induces apoptosis via death receptor 5 (DR5) upregulation through CHOP-dependent and PKC delta-independent mechanism in human malignant tumor cells' have been presented. "Rottlerin has been shown to induce antiproliferation and apoptosis of human cancer cell lines. In this study, we demonstrate a novel mechanism of rottlerin-induced apoptosis via death receptor (DR) 5 upregulation," researchers in South Korea report. "We found that treatment with rottlerin significantly induces DR5 expression both at its messenger RNA and protein levels. Downregulation of DR5 expression with small-interfering RNA (siRNA) efficiently attenuated...
Source: Cancer Weekly (2009-05-19)
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